double-strand dna breaks — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9168	NSC 617145	NSC617145,NSC-617145	DNA/RNA Synthesis
	NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner.		DNA/RNA Synthesis
T24925	UNC-2170	UNC2170 Maleate,UNC-2170 Maleate,UNC 2170 Maleate	Others
	UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.		Others
T14858	Calicheamicin	Calicheamicin γ1	Others
	Calicheamicin (Calicheamicin γ1) is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks.		Others
T6228	Irinotecan	CPT-11,Topotecin,(+)-Irinotecan	Topoisomerase , Autophagy
	Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting...		Topoisomerase , Autophagy
T63228	Simmiparib	SMOCL-9112	Apoptosis , PARP
	Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR)-deficient...		Apoptosis , PARP
T3157	COH29	RNR Inhibitor COH29	DNA/RNA Synthesis
	COH29 (RNR Inhibitor COH29) is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity. Upon oral administration, the RNR i...		DNA/RNA Synthesis
T16283	Neocarzinostatin		5-HT Receptor
	Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic. It recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin leads to apoptosis. Neocarzinostatin has potenti...		5-HT Receptor
T21303	Etoposide Phosphate	Eposin Etopophos Vepesid VP16
	Etoposide phosphate is a phosphate salt of Etoposide, which binds to the enzyme topoisomerase II, then induces double-strand DNA breaks and inhibits DNA repair, leading to decreased DNA synthesis and tumor cell prolifera...
T19149	5-BrdUTP sodium salt	5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt	Others
	5-BrdUTP sodium salt is a TdT substrate that can be used to label the DNA double-strand breaks.		Others
T68985	Amonafide L-malate
	Amonafide L-malate is the malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-s...
T68672	Amsacrine lactate
	Amsacrine lactate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resultin...
T68673	Amsacrine gluconate
	Amsacrine gluconate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, result...
T68671	Amsacrine Isothionate
	Amsacrine Isothionate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resu...
T79330	PARP-1-IN-13		PARP
	PARP-1-IN-13 (Compound 19c) is a potent PARP-1 inhibitor with an IC50 of 26 nM, hindering DNA single-strand break repair and exacerbating DNA double-strand breaks. It induces apoptosis in cancer cells via the mitochondri...		PARP
T78747	DiPT-4		Topoisomerase
	DiPT-4, a dual TOP1/PARP1 inhibitor, effectively induces DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells, with potential to circumvent drug resistance [1].		Topoisomerase
T78581	Selenocystine		Others
	Selenocystine, a broad-spectrum anticancer agent, effectively induces DNA damage, notably DNA double-strand breaks (DSBs), in HepG2 cells, showcasing significant potential as a therapeutic or adjuvant agent in targeting ...		Others
T73023	PARP1-IN-12
	PARP1-IN-12, a potent inhibitor of PARP1, demonstrates an IC50 value of 2.99 nM. It exhibits antiproliferative effects, induces apoptosis, and causes cell cycle arrest in the G2/M phase. Additionally, PARP1-IN-12 induces...
T80899	UNC3474
	UNC3474, a small molecule ligand, selectively interacts with the aromatic methyl-lysine binding cage of the tumor protein 53BP1 Tudor domain (TT), exhibiting a dissociation constant (Kd) of 1.0±0.3 μM. It impedes 53BP1's...
T35770	Cylindrospermopsin
	Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of ...
T79405	PARP1-IN-15		PARP
	PARP1-IN-15 (Compound 6) is a PARP1 inhibitor that also inhibits tankyrase (TNKS) and promotes DNA double-strand breaks, leading to tumor cell apoptosis. It exhibits anti-cancer activity in triple-negative breast cancer ...		PARP